Stemedil MD is a mouth-dissolving tablet containing Prochlorperazine maleate 5 mg, a medication with both antipsychotic and antiemetic properties. It is prescribed for managing severe nausea and vomiting, vertigo or dizziness (such as in Ménière’s disease), and certain psychotic or anxiety conditions where short-term relief is needed.

Mechanism of Action
Prochlorperazine primarily works by blocking dopamine D₂ receptors in the brain, especially in the chemoreceptor trigger zone (CTZ) that controls nausea and vomiting. This reduces the vomiting reflex and has an antipsychotic effect through dopamine receptor blockade in the mesolimbic system, modulating neurotransmitter activity. There is also some serotonin 5‑HT₃ receptor antagonism, contributing to its antiemetic effect.

Uses
Stemedil MD is used for:

• Preventing and treating nausea and vomiting caused by chemotherapy, radiotherapy, surgery, or migraine 

• Managing vertigo and dizziness related to inner ear disorders like Ménière’s disease

• Short‑term treatment of non‑psychotic generalized anxiety, acute mania, and schizophrenia symptoms such as hallucinations and hostility

  Adverse Effects
  Common and infrequent side effects include:

  • Drowsiness or sedation, which may impair ability to drive or operate machinery

  • Orthostatic hypotension (a sudden drop in blood pressure when standing), especially at the start of therapy

  • Dry mouth, blurred vision, and constipation from anticholinergic effects

  • In rare or prolonged use: extrapyramidal symptoms, blood disorders such as leukopenia or thrombocytopenia, liver function changes, and cardiac arrhythmias including QT prolongation