POLY-B contains Polymyxin B, an antibiotic mainly used to treat serious bacterial infections caused by Gram-negative bacteria. It is often reserved for infections that do not respond to other antibiotics. POLY-B is usually given by injection in hospitals, particularly in intensive care settings, and sometimes used topically for skin and eye infections.

Mechanism of Action:

Polymyxin B works by:

• Attaching to the outer membrane of Gram-negative bacteria

• Disrupting the bacterial cell wall structure

• Causing leakage of cell contents

• Leading to bacterial cell death

  Uses:

  POLY-B is used for treating serious infections such as:

  • Bloodstream infections (sepsis) caused by multidrug-resistant Gram-negative bacteria

  • Urinary tract infections

  • Pneumonia, especially hospital-acquired or ventilator-associated

  • Meningitis in selected cases

  • Skin, eye, and wound infections (topical formulations)

    Adverse Effects:

    Polymyxin B can have significant side effects, especially when given by injection:

    Common side effects:

    • Pain or swelling at the injection site

    • Fever or dizziness

    • Skin irritation (when used topically)